Which of the following statements regarding enzyme inhibition is correct?

1. A. Non competitive inhibitors often bind to the enzyme irreversibly
2. B. Competitive inhibition is seen when substrate competes with an enzyme for binding to an inhibition protein.
3. C. Competitive inhibition is seen when the substrate and the inhibitor compete.
4. D. Non competitive inhibition of an enzyme can be overcome by adding large amount of substrate.

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